Bruce Beutler

The Saga of Bruce Beutler

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Profile & Early Foundations

Bruce Alan Beutler ( BOYT-lər; born December 29, 1957) is an American immunologist and geneticist. Together with Jules A.

THE JOURNEY & BREAKTHROUGHS

Major Works & Significant Milestones

Hoffmann, he received one-half of the 2011 Nobel Prize in Physiology or Medicine, for "discoveries concerning the activation of innate immunity." Beutler discovered the long-elusive receptor for lipopolysaccharide (LPS; also known as endotoxin).

Key Milestone & Career Defining Moment

Bruce Alan Beutler ( BOYT-lər; born December 29, 1957) is an American immunologist and geneticist.

— Official Historical Record & Archive

SUCCESS & ENDURING LEGACY

Honours, Standing & Enduring Legacy

He did so by identifying spontaneous mutations in the gene coding for mouse Toll-like receptor 4 (Tlr4) in two unrelated strains of LPS-refractory mice and proving they were responsible for that phenotype.

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Profile & Early Foundations

Major Works & Significant Milestones

Honours, Standing & Enduring Legacy

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